Amino Acid Building Blocks for Fmoc Solid-Phase Synthesis of Pep

Amino Acid Building Blocks for Fmoc Solid-Phase Synthesis of Peptides Phosphocholinated at Serine, Threonine, and Tyrosine

Michael F. Albers and Christian Hedberg
J. Org. Chem., Article ASAP
DOI: 10.1021/jo302587g
Publication Date (Web): February 1, 2013
Copyright © 2013 American Chemical Society

Phosphocholination of eukaryotic host cell proteins has recently been identified as a novel post-translational modification important for bacterial pathogenesis. Here, we describe the first straightforward synthetic strategy for peptides containing phosphocholinated serine, threonine, or tyrosine residues using preformed functional amino acid building blocks, fully compatible with standard Fmoc solid-phase peptide synthesis.